Non-stationary Stochastic Optimization

We consider a non-stationary variant of a sequential stochastic optimization problem, in which the underlying cost functions may change along the horizon. We propose a measure, termed variation budget, that controls the extent of said change, and study how restrictions on this budget impact achievable performance. We identify sharp conditions under which it is possible to achieve long-run-average optimality and more refined performance measures such as rate optimality that fully characterize the complexity of such problems. In doing so, we also establish a strong connection between two rather disparate strands of literature: adversarial online convex optimization; and the more traditional stochastic approximation paradigm (couched in a non-stationary setting). This connection is the key to deriving well performing policies in the latter, by leveraging structure of optimal policies in the former. Finally, tight bounds on the minimax regret allow us to quantify the "price of non-stationarity," which mathematically captures the added complexity embedded in a temporally changing environment versus a stationary one

Geometric approach to sampling and communication

Relationships that exist between the classical, Shannon-type, and geometric-based approaches to sampling are investigated. Some aspects of coding and communication through a Gaussian channel are considered. In particular, a constructive method to determine the quantizing dimension in Zador's theorem is provided. A geometric version of Shannon's Second Theorem is introduced. Applications to Pulse Code Modulation and Vector Quantization of Images are addressed.Comment: 19 pages, submitted for publicatio

Induction of graft acceptance after dog kidney or liver transplantation

We have reported that, a short delayed course of intramuscular FK 506 can induce a,donor strain-specific immunologic unresponsiveness to cardiac allograft in rats.1 Further studies have been performed to determine if this agent can induce graft acceptance after canine renal (KT) or hepatic (OLT) allotransplantation. Preliminary descriptions of these efforts have been published.